Figure 4

ANDRO recovers the cognitive functions and LTP in an AD mouse model of different ages . (a) Behavioral performance in the memory flexibility test. Seven-month-old AβPPswe/PS-1 mice treated with control vehicle solution (Wt, gray circles and AβPPswe/PS-1 control, white circles) or with ANDRO (AβPPswe/PS-1 ANDRO, black circles). (b) Behavioral performance was evaluated by the escape latency in the classical MWM test. Twelve-month-old Wt and AβPPswe/PS-1 mice were treated with vehicle solution (Wt, gray circles and AβPPswe/PS-1 control, white circles) or with ANDRO (AβPPswe/PS-1 ANDRO, black circles), n ≥ 5. *p < 0.05. (c) LTP was generated by TBS in hippocampal CA1 in AβPP/PS1 slices from 7-month-old ANDRO-treated mice (black circle) shows a recovery in the capacity to induce LTP in comparison with AβPP/PS1 control mice (white circles). (d) LTP generated by TBS in hippocampal CA1 in AβPP/PS1 slices from 12-month-old mice treated with vehicle solution or with ANDRO shows a recovery in the capacity to induce LTP in comparison with AβPP/PS1 control mice (white circles). The dots and bars represent the mean ± SE from 7 different slices. *p < 0.05. Data are presented as means ± S.E.M. Three animals were used per experimental group. Data are presented as mean ± SEM. Statistical differences were calculated by Student’s t test, followed by Dunnett’s post hoc test. Asterisks indicate statistically significant differences (*p < 0.05). Statistical significant differences in behavioral experiments were calculated by one-way ANOVA, followed by Bonferroni’s post hoc test.