Figure 1
From: Effects of the C57BL/6 strain background on tauopathy progression in the rTg4510 mouse model
Breeding scheme for comparison of rTg4510 mice on different strain backgrounds. Breeding scheme used to produce rTg4510 mice on an F1 FVB/N x C57BL/6 (FVB/B6) strain background (rTg4510B6) (Left) compared to the original rT4510 mice on an F1 FVB/N x 129S6 (FVB/129) strain background (Right). Mice used in these studies include rTg4510B6 and rTg4510 mice that carry both the tau responder and the tTA activator transgenes and non-transgenic (NTB6 and NT) mice. Single transgenic mice generated from these F1 crosses were not analyzed in these studies.