Skip to main content
Figure 8 | Molecular Neurodegeneration

Figure 8

From: Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy

Figure 8

Immunization with AFF 1 reduces behavioral impairments and TH alterations in MBP-α-syn tg mice. (A) Performance in the transversal round beam test, measured as slips per 10 cm in non-tg or MBP-α-syn tg mice immunized with vehicle or AFF 1 (B) Speed of the animals in the transversal round beam test, measured as cm per second in non-tg or MBP-α-syn tg mice immunized with vehicle or AFF 1 (C) Quantification of TH staining by optical density in striatum. Results are expressed as average ± SEM. (*) p < 0.05 when comparing vehicle-treated non-tg animals to vehicle-treated tg animals by one-way ANOVA with post hoc Dunnett; (#) p < 0.05 when comparing vehicle-treated tg animals with AFF 1-treated tg animals by one-way ANOVA with post hoc Tukey-Kramer. For the non-tg group, animal numbers were n = 5 for vehicle and n = 3 for AFF 1. For tg groups, n = 10 animals per group.

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326