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Figure 1 | Molecular Neurodegeneration

Figure 1

From: Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration

Figure 1

Overexpression of α-SYN or eGFP in mouse SN with high titer rAAV2/7 vectors. Immunohistochemical staining for TH (left panels) shows cell loss in the injected side of both the parkin−/− and the parkin+/+ mice at 4 weeks after injection with a high titer of rAAV2/7-WT α-SYN. Immunohistochemical stainings for α-SYN and eGFP (middle and right panels) show wide expression of these proteins in the injected side of the SN. Right panels are magnifications of the adjacent left panel. Scale bars overviews = 400 μm and magnifications = 50 μm.

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Molecular Neurodegeneration

ISSN: 1750-1326