Table 2 Fluorine and deoxy CA analogs EC50 for lowering Aβ42
From: Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator
| |||
|---|---|---|---|
R1 | R2 | Cmpd # | Aβ42 EC50 (nM) |
β-F | α-H | 12 | 8906 |
β-H | β-H | 13 | 671 |
From: Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator
| |||
|---|---|---|---|
R1 | R2 | Cmpd # | Aβ42 EC50 (nM) |
β-F | α-H | 12 | 8906 |
β-H | β-H | 13 | 671 |
Molecular Neurodegeneration
