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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice

Fig. 3

Viral expression of human ubiquilin-2 in whole brain lysates. Western blots of brain lysates from 3 and 6 month animals demonstrate sustained expression of WT ubiquilin-2 and mutants. In the Trition-X100 soluble fraction (a) three bands are seen for ubiquilin-2: top is mouse UBQLN2 whereas middle and lower (truncated?) bands represent human UBQLN2. b) Only mutant forms of human UBQLN2 are seen in the Triton insoluble fractions. c) Graph of human vs endogenous mouse UBQLN2 expression in whole brain (Triton soluble) lysates. N = 2–3 sample each with mean ± SD ratio shown

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Molecular Neurodegeneration

ISSN: 1750-1326