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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice

Fig. 5

Ubiquilin-2 inclusions colocalize with ubiquitin, p62, and optineurin. Merged immunofluorescent images are from a) cortex and b) hippocampus from 6 month mice and show staining for ubiquitin/p62/optineurin (red), ubiquilin-2 (green), and DAPI (blue). In contrast to WT, pathological (mutant) ubiquilin-2 form large intracellular and neuropil inclusions that frequently colocalize (indicated as yellow, representing overlap red and green signal) with ubiquitin, p62, and optineurin. (bar = 25 μm)

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Molecular Neurodegeneration

ISSN: 1750-1326