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Fig. 8 | Molecular Neurodegeneration

Fig. 8

From: Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice

Fig. 8

Behavioral deficits in mice. a) Mice expressing ALS-mutant ubiquilin-2 develop a clasping phenotype at 3–4 months. b) Rotarod performance for mice at 3 months expressing mutant ubiquilin-2 P497S (p < 0.0001) and P506T (p < 0.01) was significantly impaired compared to those expressing WT ubiquilin-2. Data shown as mean ± SEM; N = 9 for each group

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Molecular Neurodegeneration

ISSN: 1750-1326