Skip to main content
Fig. 10 | Molecular Neurodegeneration

Fig. 10

From: Prophylactic melatonin significantly reduces Alzheimer’s neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPPswe/PS1 mice

Fig. 10

Melatonin treatment effect on anti-oxidant transcript expression in frontal cortex of 13-month old mice. Melatonin significantly (p < 0.05) lowered transcript levels for four markers of the antioxidant response system in a receptor-mediated fashion. This effect was seen in both NonAD and 2xAD mice that possessed melatonin receptors (MTNR+), but not in mice that lacked these (MTNR-). Evaluated with 2-way ANOVA; n = 4–6; error bars represent SEM

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326