Fig. 2

Behavioral phenotypes of hNSC- or vehicle-injected NSE/APPsw transgenic mice and vehicle-injected wild-type mice. a Ambulatory and stereotypic activity of the three groups in a 30 min open field test (APP-NSC, n = 24; APP-Veh, n = 20; and WT-Veh, n = 24). b Ambulatory and stereotypic locomotor activity over 22 h (APP-NSC, n = 12; APP-Veh, n = 8; and WT-Veh, n = 14). c Latency to fall in the accelerating rotarod task (APP-NSC, n = 26; APP-Veh, n = 20; and WT-Veh, n = 23). d and e Results from the water maze test 6 weeks after hNSC or vehicle injection. The latency to reach the hidden platform (escape latency) during the learning phase was recorded d. Target quadrant occupancy and platform crossing during the probe trial were measured in the three groups (APP-NSC, n = 21; APP-Veh, n = 19; and WT-Veh, n = 19; e). f and g Results from the water maze test 12 weeks post-transplantation. Escape latency during the learning phase in the three groups (f). Target quadrant occupancy and platform crossing during the probe trial (APP-NSC, n = 12; APP-Veh, n = 10; and WT-Veh, n = 10; g). The number of mice (n) in each group is indicated. All data represent mean ± SEM. Error bars indicate ± SEM. *p < 0.05, **p < 0.01