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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation

Fig. 2

α-Synuclein pathology. a Representative microscopy images of paraffin-embedded human brain tissue show abundant neuronal and neuritic α-synuclein pathology in three G51D cases compared to the H50Q mutation and SNCA duplication cases stained for α-synuclein protein. High magnification images from CA3, caudate (Cd), substantia nigra (SN), putamen (Pt) and dentate fascia (DF). b Distinctive neocortical ‘tramline’ deposition of α-synuclein is only detected in G51D cases (i, ii), shown in representative low (i) and high (ii) magnification images of the entorhinal cortex, while in H50Q (iii, iv) and SNCA duplication (v, vi) α-synuclein deposition was detected only in the deep cortical layers (iv, vi). Scale bars represent 50 μm

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Molecular Neurodegeneration

ISSN: 1750-1326