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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation

Fig. 3

5G4 α-synuclein. The 5G4 α-synuclein antibody has high affinity for high molecular weight α-synuclein oligomers with lesser affinity for fibrils and low affinity for monomeric α-synuclein. Representative images show 5G4 positive α-synuclein accumulation in areas of severe inclusion burden in G51D (HC, hippocampus, CA1, cornu ammonis 1, DF, dentate fascia) SNCA duplication and H50Q (SN, substantia nigra). Scale bars represent 50 μm

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Molecular Neurodegeneration

ISSN: 1750-1326