Fig. 4
From: Caspase-7: a critical mediator of optic nerve injury-induced retinal ganglion cell death
Cleavage of caspase-7 selective substrates by ON crush. a Representative western blot images of uncleaved and cleaved PARP, kinectin, as well as cleaved and uncleaved co-chaperone P23 in retinal protein extracts from WT or Casp7 −/− mice, uninjured or 7 d after ON crush. b-d Densitometry analysis of the corresponding western blot images showing that ON crush induced hydrolysis of kinectin and P23 only in the WT mouse. The values were normalized to β-actin and presented as the mean ± SD (n = 4). *: p < 0.05 by One Way-ANOVA then Tukey–Kramer post hoc test