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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells

Fig. 6

Subcellular vesicle components and tau mRNA levels in the cortices of PPND/FTDP-17 patients with N279K tau mutation. a-f Western blot analysis of EEA1, CHMP2B and LAMP-1 levels in the frontal a, b, temporal c, d and occipital e, f cortex from non-demented controls (n = 4) and PPND/FTDP-17 patients (n = 4). g Quantitative RT-PCR for levels of 3R-tau and 4R-tau mRNA in the frontal, temporal and occipital cortex from control non-demented controls (n = 4) and PPND/FTDP-17 patients (n = 4). Relative gene expression represents fold changes relative to control patient levels, normalized to β-actin. Data are mean ± SEM. *p < 0.05. N.S, Not Significant

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Molecular Neurodegeneration

ISSN: 1750-1326