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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverses motor deficits in a rat model of Parkinson’s disease

Fig. 3

Lactacystin lesioning induces a nigral dopaminergic lesion that closely resembles clinical PD. a Stereological quantification of TH+ neurons in the SNc on the lactacystin-lesioned side reveals a near 50 % loss of TH+ neurons, when compared to the same hemispheric side of sham-lesioned rats (n = 12/group). Mean ± SEM, ***p <0.001. b Representative Bright field images using a 4×/0.10 NA air objective taken of TH+ neurons in coronal brain sections containing the SNc at 5 weeks post-surgery for all experimental groups. Scale bar: 200 μm

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Molecular Neurodegeneration

ISSN: 1750-1326