Fig. 5
Effect of the microtubule-stabilizing drug EpoD on dendritic simplification. a Total path length and number of branching points of CA1 neurons in the presence of EpoD. Schematic representation of the time line of the experiment is shown on top. EpoD causes dendritic simplification on a non-transgenic background. b, c 3D reconstructions of representative CA1 neurons (c) and Sholl analysis (b) from APPSDL transgenic and non-transgenic (B6) mice in the presence of EpoD illustrating similar complexity in the basal (blue) and apical (red) part of the dendritic tree. (#, ##) indicate significant decrease compared to the respective condition without EpoD. Statistical evaluation was performed using one way ANOVA with post hoc Fisher’s LSD test for multiple comparisons (a) and Student’s t test for comparison of the two genotypes (b). Values are shown as mean and s.e.m. *(#), p < 0.05, (##), p < 0.01. See Table 2 for details on the statistics