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Table 1 Half-lives of various tau species in pro-aggregant mice and anti-aggregant mice

From: Analysis of in vivo turnover of tau in a mouse model of tauopathy

Pro-aggregant mice
  half-life (t1/2, day) R2
 Intracellular soluble 9.7 0.91
 Extracellular soluble 17.3 0.7
 P   0.06
 intracellular soluble 9.7 0.91
 intracellular soluble pS202/pT205 5.7 0.8
 P   0.12
 intracellular soluble 9.7 0.91
 intracellular soluble pT231/pS235 5.2 0.88
 P   <0.0001
 intracellular soluble 9.7 0.91
 intracellular insoluble 34.2 0.43
 P   <0.0001
 intracellular soluble 9.7 0.91
 intracellular soluble pS396 9.8 0.51
 P   0.52
Anti-aggregant mice
  half-life (t1/2, day) R2
 Intracellular soluble 11.1 0.96
 Extracellular soluble 10.9 0.91
 P   0.44
  half-life (t1/2, day) R2
 intracellular soluble 11.1 0.96
 intracellular soluble pS202/pT205 7.5 0.89
 P   0.022
  half-life (t1/2, day) R2
 intracellular soluble 11.1 0.96
 intracellular soluble pS396 7.6 0.64
 P   0.24