Table 1 Half-lives of various tau species in pro-aggregant mice and anti-aggregant mice

half-life (t_1/2, day)

R²

 Intracellular soluble

9.7

0.91

 Extracellular soluble

17.3

0.7

 P

0.06

 intracellular soluble

9.7

0.91

 intracellular soluble pS202/pT205

5.7

0.8

 P

0.12

 intracellular soluble

9.7

0.91

 intracellular soluble pT231/pS235

5.2

0.88

 P

<0.0001

 intracellular soluble

9.7

0.91

 intracellular insoluble

34.2

0.43

 P

<0.0001

 intracellular soluble

9.7

0.91

 intracellular soluble pS396

9.8

0.51

 P

0.52

half-life (t_1/2, day)

R²

 Intracellular soluble

11.1

0.96

 Extracellular soluble

10.9

0.91

 P

0.44

half-life (t_1/2, day)

R²

 intracellular soluble

11.1

0.96

 intracellular soluble pS202/pT205

7.5

0.89

 P

0.022

half-life (t_1/2, day)

R²

 intracellular soluble

11.1

0.96

 intracellular soluble pS396

7.6

0.64

 P

0.24