Fig. 6From: Novel (Hetero)arylalkenyl propargylamine compounds are protective in toxin-induced models of Parkinson’s diseaseThe effect of SZV558 on the behavior in the chronic MPTPp induced PD in mice. Adult mice were treated with vehicle plus probenecid, or MPTP (25 mg/kg i.p.) plus probenecid (100 mg/kg i.p.), administered 30 min before each MPTPp, twice a week for 5 weeks, alone, or in the presence of the SZV558 (1 mg/kg i.p.) or rasagiline (1 mg/kg i.p.) administered 18 h before each MPTPp administration. a-b Beam-walking test. To evaluate the number of steps (a) and the total errors (b), the mice were videotaped for a total of five trials, 2 days after the 10th MPTPp administration. The number of steps and the number of errors were calculated across all five trials and averaged for each group. * P < 0.05 compared with vehicle, # P < 0.05 compared with MPTPp. c Inverted grid test. To assess skilled forepaw use, the latency time of falling down was measured 2 days after the 10th MPTPp administration. d Olfactory test. To evaluate the olfactory deficit, the retrieval time of a buried smelling pellet was measured 3 days after the 10th MPTPp administration. * P < 0.05 compared with MPTPp. Values are expressed as mean ± SEM. Data were statistically compared with one-way ANOVA, followed by the Newman-Keuls post hoc test. N: 4–7/groupBack to article page