Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease

Table 4 Logistic regression analysis of CSF biomarkers between PD and HC

Predictor	AUC	Sensitivity	Specificty	p value
t-α-syn	0 · 70	65 %	74 %	0 · 001
p-S129-α-syn	0 · 67	65 %	54 %	<0 · 0001
o-α-syn	0 · 77	89 %	52 %	< 0 · 0001
p-S129/t-α-syn %	0 · 76	80 %	56 %	< 0 · 0001
o-/t-α-syn %	0 · 82	68 %	85 %	< 0 · 0001
o-/t-α-syn %, p-S129-α-syn & p-tau	0 · 86	79 %	67 %	< 0 · 0001

Abbreviations: t-α-syn total α-synuclein, p-S129-α-syn phosphorylated Ser 129 α-synuclein, o-α-syn oligomeric α-synuclein, p-tau phosphorylated-tau, AUC area under the curve

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