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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells

Fig. 6

Aβ1-40- and Aβ1-42-mediated ROS production is not dependent on intracellular Ca2+ influx. Transformed rat cerebral VSMC were loaded with Mitotracker Red CM-H2XRos (5 μM) and treated with either Aβ1-40 or Aβ1-42 in the presence or absence of EGTA (5 mM) in the extracellular media (panel a). Aβ1-40-mediated ROS production in VSMC was measured after 5 minutes and compared with ROS production after 30 minutes (panel b). Aβ1-40-mediated changes in VSMC surface area were measured after 5 minutes and compared with VSMC surface area after 30 minutes (panel c)

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Molecular Neurodegeneration

ISSN: 1750-1326