Fig. 12From: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosisGender similarities and differences in the effect of ADAMTS-4 treatment on ALS. a Schematic representation of ADAMTS-4 treatment promoting the decline of NGF production and ALS-induced perineuronal net degradation which contribute to the degeneration and even death of motoneurons in the ventral horn of the lumbar spinal cord of SOD1G93A mice. b A table describing the similarities and differences observed in behavioral and anatomical effects of ADAMTS-4 treatment in SOD1G93A male and female miceBack to article page