Fig. 6
From: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
rADAMTS-4 accelerates neurodegeneration in the lumbar spinal cord of SOD1G93A mice. a Representative photomicrographs of ventral horns in lumbar spinal cord sections from WT and control or ADAMTS-4-treated SOD1G93A male mice stained with ChAT. Scale bar: 500 or 250 μm. b-c Quantification of average spinal motoneuron number (b) and size (c) in male mice from (a). Values plotted are mean ± SEM. Two-way ANOVA: *** P < 0.001 WT Vs SOD1G93A. Unpaired two-tailed t-Test: P > 0.05 (Number) or $ P < 0.05 (Size) Control Vs ADAMTS-4 SOD1G93A, N = 3 Control WT, N = 5 ADAMTS-4 WT, N = 8 Control SOD1G93A, N = 7 ADAMTS-4 SOD1G93A. d Representative photomicrographs of ventral horns in lumbar spinal cord sections from WT and control or ADAMTS-4-treated SOD1G93A female mice stained with ChAT. Scale bar: 500 or 250 μm. e-f Quantification of average spinal motoneuron number (e) and size (f) in female mice from (d). Values plotted are mean ± SEM. Two-way ANOVA: *** P < 0.001 WT Vs SOD1G93A. Unpaired two-tailed t-Test: $ P < 0.05 (Number) or P > 0.05 (Size) Control Vs ADAMTS-4 SOD1G93A, N = 5 Control WT, N = 3 ADAMTS-4 WT, N = 5 Control SOD1G93A, N = 6 ADAMTS-4 SOD1G93A