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Table 1 List of commonly dysregulated genes in the cortex and hippocampus of transgenic and wild type mice

From: Vitamin D interacts with Esr1 and Igf1 to regulate molecular pathways relevant to Alzheimer’s disease

  

Fold change

  

Hipocampus

Cortex

Gene symbol

Entrez gene name

WtVitD/Wt

TgVitD/Tg

WtVitD/Wt

TgVitD/Tg

Ahcy

adenosylhomocysteinase

−1,73

−2,07

1,79

2,07

Atg4c

autophagy related 4C, cysteine peptidase

−2,72

−2,75

4,49

4,82

Avp

arginine vasopressin

−1,59

2,21

1,73

3,96

C130078n14

uncharacterized protein C130078N14

−2,13

−2,17

3,92

2,77

Cdk5rap1

CDK5 regulatory subunit associated protein 1

−1,78

−2,14

2,66

2,92

Cpne1

copine I

−1,56

−1,82

1,6

1,71

Dnajb8

DnaJ (Hsp40) homolog, subfamily B, member 8

−1,85

1,98

−1,92

−1,73

Fam205a

family with sequence similarity 205, member A

2,34

2,78

1,61

−1,55

Fkbp1a

FK506 binding protein 1A, 12kDa

1,97

1,62

−1,72

−1,52

Gbp6

guanylate binding protein family, member 6

2,19

2,21

−2,65

−3,23

Gm4924

predicted gene 4924

1,68

1,94

2,14

1,53

Hla-drb5

major histocompatibility complex, class II, DR beta 5

1,86

1,53

−2,53

−2,34

Iqcf4

IQ motif containing F4

2,74

2,22

−1,54

−1,73

Iqsec3

IQ motif and Sec7 domain 3

−5,23

4,49

−3,3

1,58

Kcnj6

potassium channel, inwardly rectifying subfamily J, member 6

1,61

1,93

−1,79

−1,67

Kdr

kinase insert domain receptor

−1,6

1,68

1,53

−1,64

Mirg

miRNA containing gene

−1,91

1,88

−3,41

−1,68

Nanog

Nanog homeobox

−2,91

1,53

−1,52

−1,66

Ocel1

occludin/ELL domain containing 1

−3,07

−3,98

3,52

3,21

Omp

olfactory marker protein

−1,54

−10,41

3,18

1,66

Oxt

oxytocin/neurophysin I prepropeptide

−2,75

4,04

2,03

4,74

Ppp1r16b

protein phosphatase 1, regulatory subunit 16B

2,29

2,39

−1,78

−1,78

Prkcd

protein kinase C, delta

−2,18

−2,52

1,84

1,65

Prl

prolactin

1,93

−1,88

10,07

10,54

Rnase4

ribonuclease, RNase A family, 4

1,61

2,12

−2,14

−2,07

Sdc4

syndecan 4

2,38

1,95

−1,91

−1,81

Serpina3g

serine (or cysteine) peptidase inhibitor, clade A, member 3G

2,78

1,94

−1,8

−2,42

Znf669

zinc finger protein 669

−2,08

−1,9

1,84

2,2

  1. Dysregulated transcripts in the hippocampus and cortex of vitamin D3 supplemented wild type and transgenic mice in comparison with unsupplemented littermates. The gene symbol, the full name and the fold change of each gene are indicated