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Table 1 Co-localization coefficient of inflammasome proteins.

From: The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease

PCC severe AD MILD AD MCI HC
NLRP1+ PYCARD + 0.8ac (0.7-0.82) 0.8 de (0.7-0.82) 0.5ad (0.3-0.6) 0.4ce (0.3–0.5)
NLRP1+ CASPASE-1+ 0.6 (0.4-0.7) 0.8 (0.7-0.84) 0.6 (0.4-0.65) 0.5 (0.5-0.7)
NLRP1+ CASPASE-5+ 0.7bac (0.5–0.8) 0.4b (0.23-0.5) 0.3a (0.1-0.32) 0.3c (0.2-0.5)
NLRP3+ PYCARD + 0.8ac (0.6-0.82) 0.8 de (0.7-0.82) 0.6ad (0.5-0.7) 0.5ce (0.4-0.6)
NLRP3+ CASPASE-1+ 0.9bac (0.8-0.9) 0.8bde (0.5-0.8) 0.5ad (0.4-0.56) 0.3ce (0.3-0.4)
NLRP3+ CASPASE-8+ 0.8ac (0.7-0.85) 0.6 (0.5-0.72) 0.5a (0.3-0.55) 0.5c (0.3-0.6)
  1. Median values, interquartile range and statistical significances are presented (p <0.05)
  2. aAD vs. MCI
  3. bAD vs. MILD AD
  4. cAD vs. HC
  5. dMILD AD vs. MCI
  6. eMILD AD vs. HC
Pearson’s co-localization coefficient (PCC) of NLRP1 and NLRP3 with PYCARD, caspase-1, caspase-5 and caspase-8, in LPS-primed and Aβ42−stimulated CD14+ monocyte of patients with a diagnosis of either severe or moderate (MILD) Alzheimer’s Disease (AD) and mild cognitive impairment (MCI). Result obtained in and in age-and sex-matched healthy controls (HC) are also shown. Index reference values: PC range= −1 and +1