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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: In vitro and in vivo neuroprotective effects of cJun N-terminal kinase inhibitors on retinal ganglion cells

Fig. 2

Retinal I/R induced phosphorylation of JNK and c-Jun. Mouse retinas were collected at 1, 6, 12, 24, and 72 h post I/R injury. The 0 h control represents the non-injured group. Western blotting analyses were conducted using total retinal proteins. a Representative images of phosphorylated JNK (pJNK), total JNK, and loading control GAPDH as well as ratio of pJNK versus total JNK, analyzed by ImageJ. JNK phosphorylation was significantly (p < 0.05) increased at 1 h after I/R injury by 2.87 (±1.87) fold compared to 0 h control. b Representative images of phosphorylated c-Jun (pc-Jun), total c-Jun, and loading control GAPDH as well as ratio of pc-Jun versus total c-Jun analyzed by ImageJ. Bars represent mean ± SEM (n = 3). Asterisk indicates statistical difference (p < 0.05) compared to the 0 h control group by One-way ANOVA then Dunnett’s test

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Molecular Neurodegeneration

ISSN: 1750-1326