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Table 3 Characteristics of individuals enrolled in this study

From: Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia

  

c.709-1G > A mutation carriers

 

Control n = 10

Asymptomatic n = 12

FTLD patients n = 7

Age (years)

51.8 ± 4.3

52.8 ± 4.3

65.3 ± 2.3

Sex, female, % (n)

50 % (5)

50 % (6)

100 % (7)

Age at onset

-

-

61 ± 0.6

Phenotype

Asymptomatic

Asymptomatic

FTD-bv; CBS

Family history, % (n)

70 % (7)

54.5 % (6)

57.1 % (4)

  1. Control: Individuals without sing of neurological degeneration; c.709-1G > A: GRN mutation carriers; n: number of subjects. Values are expressed as mean ± SEM. CBS Cortico-basal syndrome, FTD-bv Frontotemporal dementia (behavior)
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Molecular Neurodegeneration

ISSN: 1750-1326