Fig. 4
From: Early-life stress leads to impaired spatial learning and memory in middle-aged ApoE4-TR mice
Decreased GABAergic neurons in the prefrontal cortex of 12-month-old ApoE4-TR mice that underwent early-life CUMS intervention. Immunohistochemical staining of anti-GABA in the prefrontal cortex of 3-month-old and 12-month-old ApoE-TR mice. The dark brown dots represent the anti-GABA–positive GABAergic neurons. Magnified areas indicated by boxes. N = 5 per group, expressed as mean ± SEM. one-factor ANOVA of statistical methods was used. &&& p < 0.001, ### p < 0.001, ***p < 0.001. Scale bars are 200 um