Fig. 4
From: Redundant Gs-coupled serotonin receptors regulate amyloid-β metabolism in vivo
Acute SSRI treatment has no significant effect on expression of Aβ APP metabolism genes. 2.5 month old APP/PS1 hemizygous mice were treated with 10 mg/kg citalopram or PBS by i.p. injection. 16 h later hippocampi were microdissected for qPCR analysis. a qPCR analysis for genes involved in Aβ processing or clearance showed no significant changes in expression. In contrast, the positive control, cFos, was significantly reduced to 57.5 ± 0.04 % (p < 0.05). b qPCR analysis for genes encoding signaling proteins downstream of 5-HTR showed no significant changes in expression. c qPCR analysis for 5-HTR genes showed no significant changes in expression. Data are presented as mean ± SEM. Values are normalized to the mean expression level of the PBS controls (n = 6). Statistical significance was calculated by one-way ANOVA with comparison to CaMKII and corrected for multiple comparisons. Asterisks mark p-values < 0.05. See Additional file 1 for primer sequences and database numbers