Fig. 2

Atm ^−/− mice have significantly lower blood glucose concentration compared to their wild type littermate mice. Glutamine supplementation of the Atm ^−/− mice significantly increased their blood glucose concentration. Unlike Atm ^−/− mice however, feeding glutamine had no effect on blood glucose of wild type mice. This effect was sexually dimorphic with a strong effect in males, but no effect observed in female Atm ^−/− mice. Symbols with a white circle inside indicate female mice. Statistically different by two-tailed t-test: **, p < 0.01; n.s. (not significant) p ≥ 0.05