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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Role of cytochrome c in α-synuclein radical formation: implications of α-synuclein in neuronal death in Maneb- and paraquat-induced model of Parkinson’s disease

Fig. 5

Microarray analysis of nigrostriatal tissue of MP co-exposed wild type and α-synuclein knockout mice. a Graph showing nearly similar gene expression pattern of wild-type sham-treated mice and α-synuclein knockout mice co-exposed to MP for 6 weeks. b Weighted Venn diagram for total number of genes with significantly different expression values (p-value lower than 0.05) in nigrostriatal tissue of treated animals compared to wild-type controls. c Upper panel showing upregulation of 13 pathways in wild type MP co-exposed mice compared to wild type sham-treated mice; lower panel showing downregulation of 2 pathways in MP co-exposed α-synuclein knockout mice compared to wild-type sham-treated mice. Heat maps for all these pathways are shown in Additional file 1: Figure S1. d Heat map showing changes in expression of hallmark genes in the xenobiotic metabolism pathway. e Heat map showing changes in expression of hallmark genes in the apoptotic pathway. f Heat map showing changes in expression of hallmark genes in the inflammatory response pathway. ES stands for Enrichment Score, and NES stands for Normalized Enrichment Score

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Molecular Neurodegeneration

ISSN: 1750-1326