LRRK2 at the interface of autophagosomes, endosomes and lysosomes

Table 1 PD-associated genes with a role in endomembrane trafficking. AD autosomal dominant, AR autosomal recessive

Gene	Inheritance	Role in endomembrane trafficking	References
Parkin	AR	Ubiquitination of damaged mitochondria for degradation by mitophagy	[86, 87]
PINK1	AR	Phosphorylation of mitochondria for parkin activation and mitophagy	[87–89]
DJ-1	AR	Mitophagy, mitochondrial dynamics	[87, 90, 91]
Fbxo7	AR	Mitophagy, interacts with parkin	[92]
α-synuclein	AD/risk factor	Substrate of CMA, pathogenic α-synuclein inhibits CMA and induces macroautophagy	[14, 28, 29, 93]
LRRK2	AD/risk factor	Autophagy, endomembrane trafficking	[14, 28]
Vps35	AD	Component of the retromer complex	[94, 95]
ATP13A2	AR	Lysosomal P5-type ATPase	[96]
DNAJC6	AR	Co-chaperone in clathrin-mediated trafficking	[97, 98]
SYNJ1	AR	Lipid phosphatase in clathrin mediated trafficking	[99]
GAK	Risk factor	Co-chaperone in clathrin-mediated trafficking, LRRK2 interactor	[14, 73]
Rab7L1	Risk factor	Small GTPase regulating endomembrane trafficking, LRRK2 interactor	[14, 73]
GBA	Risk factor	Lysosomal protease	[14, 100]
TMEM230	AD	Transmembrane protein of recycling/secretory vesicles	[101]

ISSN: 1750-1326