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Fig. 8 | Molecular Neurodegeneration

Fig. 8

From: GDE2 is essential for neuronal survival in the postnatal mammalian spinal cord

Fig. 8

Gde2 ablation causes progressive motor degeneration. ad Aged Gde2 KO animals display hindlimb clasping. e Grip strength shows significant interaction with genotype and animal age (F1,39 = 9.016, *p = 0.008) indicating progressive deterioration of Gde2 KO motor performance. f Fine movement in the Open Field Activity Monitor reveals significant interaction with genotype (F1,39 = 4.45, *p = 0.049). g Heat sensitization shows significant increases at 6 months and 13 months in Gde2 KOs (F1,39 = 19,749, *p < 0.001, n = 10). Graphs represent mean ± SEM, 2-way repeated measures ANOVA, n = 10

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