The SH-SY5Y cell line in Parkinson’s disease research: a systematic review

Table 4 Use of alternative cellular models in parallel to SH-SY5Y cells

Alternative cellular models	#articles
No other neuronal cell lines	772
Other neuronal (−like) cell lines	190
Mesencephalic cultures (mouse/rat)	54
Primary neurons (cortical mainly) (mouse/rat)	54
PC12 (rat)	39
Neuro-2a (mouse)	13
hESC, NPSC, hMSC, iPSCs (human)	9
SK-N-BE (2)-M17(M17) (human)	9
MN9D (mouse)	7
Other	45

The table specifies the number of articles (#articles) that do not use any neuronal cell line other than SH-SY5Y cells; and those that do use another neuronal (−like) cell line (and the most commonly used ones). Sometimes an article uses multiple alternative cell lines and, thus, the addition of the individual values of other neuronal (−like) cell lines is larger than the number of articles that use other neuronal (−like) cell lines (190). More detailed information on these other cell lines can be found in Additional file 4

ISSN: 1750-1326