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Fig. 9 | Molecular Neurodegeneration

Fig. 9

From: Gene-environment interaction between lead and Apolipoprotein E4 causes cognitive behavior deficits in mice

Fig. 9

Adult-only lead exposure does not increase the number of TUNEL+ apoptotic cells in the DG of the hippocampus. a Experimental design and timeline for cellular studies (BrdU dosing) for Figs. 9, 10, 11, 12, 13, 14, 15 and 16. b Representative images of TUNEL+ (green) cells in the DG of control and lead-treated ApoE3-KI and ApoE4-KI males and females. Quantification of TUNEL+ cells per DG in ApoE3-KI and ApoE4-KI c females and d males. Data are mean ± SEM with n = 3–4 per genotype/sex/treatment. Two-way ANOVA with Fisher’s LSD post-test: n.s., not significant. Scale bar, 50 μm

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