Fig. 7
From: Transient IKK2 activation in astrocytes initiates selective non-cell-autonomous neurodegeneration
Lcn2 does not contribute to Purkinje cell loss, astrogliosis and microgliosis in IKK2-CA mice. a Cerebellar atrophy at 20 weeks of age. Measurement of maximal rostro-caudal length of the cerebellum (single animals and mean). Statistical analysis: 1-way-ANOVA, ns: not significant (p > 0.05); *** p < 0.001. b, c Loss of Purkinje cells (arrows) at 20 weeks. Nissl-stained images (b) and quantification in the simple lobule (c). Scale bars: 25 μm. Statistical analysis: 1-way-ANOVA, ns: not significant (p > 0.05); ** p < 0.01; *** p < 0.001. d Astrogliosis, microgliosis and IKK2-CA expression indicated by GFAP, Mac2 and IKK1/2. ERK2 is detected as loading control