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Fig. 11 | Molecular Neurodegeneration

Fig. 11

From: Defining the contribution of neuroinflammation to Parkinson’s disease in humanized immune system mice

Fig. 11

MPTP injections increased levels of human inflammatory cytokines in the striatum of humanized CD34+ mice. The hCD34+ mice were intraperitoneal injected three times with saline vehicle or MPTP-HCL (18 mg/kg) at 2 h intervals followed by FK506 injections (10 mg/kg/day) for 5 days. Eight days post MPTP injections, striatum were dissected out, lysed and used for human specific multi-analyte cytokine ELISA arrays. Cytokine levels were determined from 6 animals per group ± SD (*p < 0.05)

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