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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Defining the contribution of neuroinflammation to Parkinson’s disease in humanized immune system mice

Fig. 3

FK506 provided no protection of TH immunoreactivity in the striatum and substantia nigra of MPTP injected C57BL/6 mice. C57BL/6 female mice were intraperitoneal injected three times with saline vehicle or MPTP-HCL (18 mg/kg) at 2 h intervals followed by FK506 injections (10 mg/kg/day) for 5 days. Eight days post MPTP injections, brains were dissected out and right hemispheres fixed and immunostained using anti-TH antibody. a Representative images from striatum and substantia nigra are shown at 1× magnification. b Optical density of immunopositive staining from striatum and c number of TH-positive cells from substantia nigra were measured and averaged for 4–5 sections per brain from 4 to 5 animals per group ± SD (*p < 0.05)

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