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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Tissue-type plasminogen activator exerts EGF-like chemokinetic effects on oligodendrocytes in white matter (re)myelination

Fig. 2

Migration of OPC is delayed in tPA −/− mice during corpus callosum development. a Photomicrographs from tissue sections show representative images (from 3 mice) of Olig2 immunostaining (red) and DAPI staining (blue) in the telencephalon of WT (left column) and tPA−/− (right column) mice during corpus callosum development at E15, E17, P0 and P3. Dotted lines show corpus callosum limits. b Corresponding quantifications of Olig2+ oligodendrocytes (mean ± SEM, n = 3 per group; *p < 0.05). E: embryonic day; OL: oligodendrocyte; P: postnatal day; WT: wild type. Scale bars: 100 μm

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