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Table 1 Half-maximal inhibitory concentrations (IC50)a of NWL-117 and NWL-154 against recombinant Caspase-1 to −10

From: Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice

Cpd No.

MWb

Caspase-

1

2

3

4

5

6

7

8

9

10

NWL-117

668

2.7

>100

6.96

0.38

19.54

0.60

>100

0.66

0.79

0.13

NWL-154

703

3.85

>100

1.34

1.80

4.19

0.23

>100

0.53

6.40

0.19

  1. aIC50 values are measured in μM
  2. bMolecular weight in g/mol
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Molecular Neurodegeneration

ISSN: 1750-1326