DcR3 reversed amyloid pathology in APP mice. a Representative thioflavin-S staining images in coronal brain sections from 12-month-old APP and APP/DcR3 mice. Scale bar: 100 μm.
b Quantification of the percentage of area covered by amyloid plaques in the hippocampi of APP and APP/DcR3 mice. N = 24–34 slices from 4–6 mice per genotype. c, d The hippocampal levels of guanidine soluble c total Aβ1-x and d Aβ1-42 in APP and APP/DcR3 mice were measured via ELISA. N = 6 mice per genotype. **P ≤ 0.01 versus APP mice