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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Amelioration of amyloid-β-induced deficits by DcR3 in an Alzheimer’s disease model

Fig. 6

DcR3 enhanced the IL-4+YM1+ M2a-like subtype of microglia activation in vivo and in vitro. a-c The APP/DcR3 mice had lower a TNF-α and b IL-1β levels but higher c YM1 mRNA and protein level than APP mice in the hippocampus. N = 6–16 mice per genotype. ***P ≤ 0.001; **P ≤ 0.01; *P ≤ 0.05 versus APP mice. d Cytokine array determined the cytokine levels in the conditioned medium. Levels of each cytokine in the control CM was arbitrarily set as 100%. N = 3 per group. *P ≤ 0.05

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