Fig. 3
From: Downregulating ANP32A rescues synapse and memory loss via chromatin remodeling in Alzheimer model
Downregulating ANP32A improves synaptic plasticity. a–c Arresting ANP32A overexpression in htau mice restores the slopes of fEPSP (a,b) with no influence on paired-pulse ratio (c) in hippocampal CA3 by stimulating mossy fibers. (n=7-8 slices from 4 mice for each group). d–f Arresting ANP32A overexpression in htau mice restores total, thin- and mushroom-shaped spines in the hippocampal CA3 neurons (at least 20 neurons from six to seven mice per group were analyzed by the Sholl). Bar=5 μm. Data were presented as mean ± SD. *, p<0.05, **, p<0.01 vs wt-siC; #, p<0.05; ##, p<0.01 vs htau-siC (two-way ANOVA followed by Bonferroni’ s post hoc test)