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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo

Fig. 1

OXPHOS is unchanged in brain mitochondria of TDP-43 mutant mice. a Oxygen consumption measured in freshly isolated brain mitochondria of TDP-43A315T mice (TDP-43) and non-transgenic (N-Tg) littermates at 45 days of age. Glutamate and malate were used as respiratory substrates. State 4 indicates non-stimulated respiration. State 3 (phosphorylating) respiration was induced by addition of ADP, followed by addition of FCCP to activate maximum uncoupled respiration (state 3 U). b Oxygen consumption measured as in (A) at 90 days of age. c Complex I dependent mitochondrial ATP synthesis with glutamate and malate in freshly isolated brain mitochondria of TDP-43A315T mice and N-Tg littermates at 45 and 90 days of age. d Complex II dependent ATP synthesis with succinate as substrate, in the presence of the complex I inhibitor rotenone, at 45 and 90 days of age. In all panels, male and female samples in each group are indicated by the respective sex symbols. Average values are indicated by horizontal lines ± SD

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