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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo

Fig. 2

Respiratory chain activities, membrane potential, and ROS emission are unchanged in brain mitochondria of TDP-43 mutant mice. a Complex I activity (expressed as nmoles substrate/min/mg of mitochondrial protein) in brain mitochondrial membranes from TDP-43A315T mice and N-Tg littermates at 60 days of age. b Complex IV activity in brain mitochondrial membranes from TDP-43A315T mice and N-Tg littermates at 60 days of age. c Membrane potential measured with safranin O in intact freshly isolated brain mitochondria of TDP-43A315T mice and N-Tg littermates at 60 days of age. Mitochondria were challenged with increasing concentrations of the membrane uncoupler SF6847. n = 6 mice in each group, 3 males and 3 females. d Hydrogen peroxide emission from intact freshly isolated brain mitochondria of TDP-43A315T mice and N-Tg littermates at 60 days of age measured by Amplex red fluorescence

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