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Fig. 8 | Molecular Neurodegeneration

Fig. 8

From: Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

Fig. 8

Thiamet G treatment increases O-tau levels. rTg4510 mice were treated with Thiamet G (500 mg/kg/day) for 8 weeks from 8 to 16 weeks of age. Brains were harvested at the end of study to prepare total brain homogenate, soluble and insoluble fractions. a Thiamet G treatment led to elevated O-tau in the total brain homogenate and soluble fractions as detected by TAMRA (TAM) labeling, but had no effect on total tau as detected by HT7 antibody on Western blots (HT7). The data shown are from one vehicle and one Thiamet G-treated animal and are representative of 5 animals in each group. b Quantification of O-tau normalized to total tau from the data shown in a. Unpaired t-test was used for comparison of vehicle and Thiamet G treatment p = 0.0013, 0.0008 and 0.014 for brain stock, soluble and insoluble fractions, respectively

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Molecular Neurodegeneration

ISSN: 1750-1326