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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Endoplasmic reticulum stress and inflammation in the central nervous system

Fig. 3

Inflammatory Pathways Induced by the UPR. The UPR stimulates various inflammatory pathways to alert surrounding cells of potential danger. The transient interaction between impaired proteostasis and inflammation is considered a beneficial feature of the UPR. Nevertheless, sustained UPR-induced inflammation is considered a pathological factor in many chronic disorders, such as neurodegenerative diseases. Inflammatory pathways associated with the UPR include the NF-κB, JAK1/STAT3, NOD1/2-RIPK2, JNK and p38 signaling pathways

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