Fig. 7
Impaired spatial learning and memory in PS cDKO mice at 2 months of age. a Escape latency of PS cDKO mice (n = 6) and controls (n = 6) gradually decreases during 13 days of training in the hidden platform water maze task, and the latency is significantly higher in PS cDKO mice (F1, 10 = 22.69, p < 0.001; two-way ANOVA). Path length is also gradually decreased for both PS cDKO and control mice during training, and the path length of PS cDKO mice is significantly longer, relative to control mice (F1, 10 = 9.62, p < 0.05; two-way ANOVA). b Two post-training probe trials were performed on days 7 and 13. Both PS cDKO and control mice show similar target quadrant occupancy on day 7, but PS cDKO mice show significantly reduced target quadrant occupancy on day 13 (p < 0.01; Student’s t-test). Post-hoc power analysis showed that 6 mice results in 99%, 99% and 98% power for latency, path length, and quadrant occupancies, respectively, at day 13. AR: adjacent right quadrant, T: target quadrant, AL: adjacent left quadrant, OP: opposite quadrant. All data are means ± SEM. The asterisks denote statistical significance (* p < 0.05, ** p < 0.01, *** p < 0.001)