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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy

Fig. 2

LPS, but not MPLA, causes systemic toxic inflammatory response in PLP-α-syn mice. a Heatmap demonstrates the overall log2 foldchange in the cytokine/chemokine levels in the brain and plasma as measured with the ProcartPlex Multiplex immunoassay 2 weeks after the last application of systemic low-dose LPS, MPLA50 or MPLA100. The following cytokine/chemokines of the 36-plex panel -GM-CSF, CXCL1, INF-α, IL-12p70, IL-3- were excluded from the analysis because no detectable levels were measured with this kit. b The detailed analysis of the cytokines/chemokines in the brains showed significant decrease of CCL2 and CCL4 after treatment with LPS or MPLA 100 μg. Data are means ± SEM, n = 4 per group. **p < 0.01 compared to vehicle treated mice

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Molecular Neurodegeneration

ISSN: 1750-1326