Fig. 3

Lack of conformational tau changes in AD retinas. a, b Western blot analysis of retinal extracts from 3-month-old 3xTg mice probed with MC-1 or ALZ-50 antibodies demonstrated lack of changes in transgenic mice relative to controls. c, d Densitometry confirmed the lack of variations in tau conformation-dependent markers (3-month-old 3xTg: n = 5, 3-month-old WT: n = 4). e-h Western blots of retinal homogenates and densitometry analyses from 6-month-old mice also revealed absence of tau conformational changes between transgenic and control mice (6-month-old 3xTg: n = 5, 6-month-old WT: n = 4, Students t-test, n.s.: not significant p > 0.05). Vertical lines represent non-consecutive samples from the same gel