Table 2 List of Hsps and whether their expression is up-regulated (↑), down-regulated (↓), or not changed (No ∆) in rodent models of motor neuron disease at the late-stage of disease compared to age-matched transgenic WT or non-transgenic mouse controls

HSF1

TDP-43^WT×Q331K

IB: ↓ spinal cord tissue homogenates

[117]

SOD1^G93A

IB: ↓ spinal cord tissue homogenates

[174]

αB-c (HSPB5)

SOD1^L126Z

IHC: ↑ spinal cord astroglia

IHC: ↓ spinal cord oligodendrocytes

[115]

SOD1^G93A

IHC: ↑ spinal cord astroglia

[116, 175]

SOD1^G37R

IHC: ↑ spinal cord astroglia

[116]

Hsp22 (HSPB8)

SOD1^G93A

IHC: ↑ spinal cord motor neurons

[176, 177]

Hsp25 (HSPB1)

SOD1^G93A

IHC: ↑ spinal cord astroglia

IHC: ↓ spinal cord oligodendrocytes

[53, 113, 114, 116]

SOD1^G37R

IHC: ↑ astroglia in the inferior colliculus, cerebellar white matter, brain stem, spinal cord

[79]

SOD1^L126Z

IHC: ↓ spinal cord motor neurons

[115]

SOD1^G93A _, SOD1^G85R, SOD1^G37R, SOD1^H46R/H48Q

IHC: ↑ spinal cord astroglia

IHC: ↑ spinal cord undefined neurons

[178]

Hsp40

SOD1^G93A

IHC: No ∆ spinal cord

[79]

SOD1^G93A _, SOD1^G85R, SOD1^G37R, SOD1^H46R/H48Q

IB: No ∆ spinal cord tissue homogenates

[178]

TDP-43^WT×Q331K

IB: No ∆ spinal cord tissue homogenates

[117]

Hsp60

SOD1^G93A

IHC: No ∆ spinal cord

[79]

SOD1^G93A _, SOD1^G85R, SOD1^G37R, SOD1^H46R/H48Q

IB: No ∆ spinal cord tissue homogenates

[178]

Hsp70

SOD1^G93A _, SOD1^G85R, SOD1^G37R, SOD1^H46R/H48Q

IB: No ∆ spinal cord tissue homogenates

[53, 79, 115, 178]

SOD1^G93A

IHC: ↑ “sick-appearing” spinal cord motor neurons

[179]

SOD1^G85R

IB: ↑ spinal cord tissue homogenates

[145]

Hsp90

SOD1^G93A

IHC: No ∆ spinal cord

[79]

SOD1^G93A _, SOD1^G85R, SOD1^G37R, SOD1^H46R/H48Q

IB: No ∆ spinal cord tissue homogenates

[178]

Hsp105

SOD1^G93A

IB: ↓ in spinal cord tissue homogenates

[108]