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Table 2 List of Hsps and whether their expression is up-regulated (↑), down-regulated (↓), or not changed (No ∆) in rodent models of motor neuron disease at the late-stage of disease compared to age-matched transgenic WT or non-transgenic mouse controls

From: The heat shock response in neurons and astroglia and its role in neurodegenerative diseases

Hsps Transgenic disease models Tissue or cell type Reference
HSF1 TDP-43WT×Q331K IB: ↓ spinal cord tissue homogenates [117]
SOD1G93A IB: ↓ spinal cord tissue homogenates [174]
αB-c (HSPB5) SOD1L126Z IHC: ↑ spinal cord astroglia
IHC: ↓ spinal cord oligodendrocytes
[115]
SOD1G93A IHC: ↑ spinal cord astroglia [116, 175]
SOD1G37R IHC: ↑ spinal cord astroglia [116]
Hsp22 (HSPB8) SOD1G93A IHC: ↑ spinal cord motor neurons [176, 177]
Hsp25 (HSPB1) SOD1G93A IHC: ↑ spinal cord astroglia
IHC: ↓ spinal cord oligodendrocytes
[53, 113, 114, 116]
SOD1G37R IHC: ↑ astroglia in the inferior colliculus, cerebellar white matter, brain stem, spinal cord [79]
SOD1L126Z IHC: ↓ spinal cord motor neurons [115]
SOD1G93A , SOD1G85R, SOD1G37R, SOD1H46R/H48Q IHC: ↑ spinal cord astroglia
IHC: ↑ spinal cord undefined neurons
[178]
Hsp40 SOD1G93A IHC: No ∆ spinal cord [79]
SOD1G93A , SOD1G85R, SOD1G37R, SOD1H46R/H48Q IB: No ∆ spinal cord tissue homogenates [178]
TDP-43WT×Q331K IB: No ∆ spinal cord tissue homogenates [117]
Hsp60 SOD1G93A IHC: No ∆ spinal cord [79]
SOD1G93A , SOD1G85R, SOD1G37R, SOD1H46R/H48Q IB: No ∆ spinal cord tissue homogenates [178]
Hsp70 SOD1G93A , SOD1G85R, SOD1G37R, SOD1H46R/H48Q IB: No ∆ spinal cord tissue homogenates [53, 79, 115, 178]
SOD1G93A IHC: ↑ “sick-appearing” spinal cord motor neurons [179]
SOD1G85R IB: ↑ spinal cord tissue homogenates [145]
Hsp90 SOD1G93A IHC: No ∆ spinal cord [79]
SOD1G93A , SOD1G85R, SOD1G37R, SOD1H46R/H48Q IB: No ∆ spinal cord tissue homogenates [178]
Hsp105 SOD1G93A IB: ↓ in spinal cord tissue homogenates [108]
  1. These results are from immunoblot (IB) or immunohistochemical (IHC) staining and microscopy of different CNS regions